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ChemicalBook Product Catalog Pafenolol

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Pafenolol NEW

$36.00 1mg

$84.00 5mg

$126.00 10mg

Min. Order
Purity99.01%
Cas No75949-61-0
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	Pafenolol
CAS No	75949-61-0
EC-No
Min. Order
Purity	99.01%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	Pafenolol
Description	Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.
In vivo	Pafenolol (50 mg or 100 mg; once daily; patients with essential hypertension). A submaximal exercise test was performed before and at the end of the treatment period. Pafenolol 50 mg and 100 mg significantly reduced recumbent and standing blood pressure compared with baseline with a mean reduction of 17/14 and 10/12 mm Hg on pafenolol 50 mg and 15/10 and 14/10 mm Hg on pafenolol 100 mg, respectively. Heart rate, both at rest and during exercise, was significantly reduced (p less than 0.05) on pafenolol 100 mg compared with placebo. The reduction in exercise heart rate (percent) was dose-dependent and significantly correlated to the log plasma concentration of pafenolol (r = 0.60; p less than 0.05). It can be concluded that pafenolol had a clinically relevant antihypertensive effect when given once daily. No difference between 50 and 100 mg could be demonstrated.[1]
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 50 mg/mL (148.17 mM), Sonication is recommended.
Keywords	β-adrenergic receptor \| Pgp \| P-glycoprotein \| AdrenergicReceptor \| Adrenergic Receptor
Inhibitors Related	Trifluoperazine dihydrochloride \| Octopamine hydrochloride \| Buflomedil hydrochloride \| Polyoxyethylene stearate \| Dexmedetomidine hydrochloride \| Isoprenaline hydrochloride \| D-Mannitol \| Mianserin hydrochloride \| Trazodone hydrochloride \| Atenolol \| Doxepin hydrochloride \| Cinchonine
Related Compound Libraries	Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| ReFRAME Related Library \| Neurotransmitter Receptor Compound Library \| Inhibitor Library \| Anti-Cardiovascular Disease Compound Library \| Endocrinology-Hormone Compound Library \| Bioactive Compounds Library Max \| Adrenergic Receptor-Targeted Compound Library \| GPCR Compound Library \| Anti-Cancer Compound Library \| Human Metabolite Library

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