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ChemicalBook Product Catalog API Other Chemical drugs palovarotene

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palovarotene NEW

$54.00 5mg

$94.00 10mg

$229.00 25mg

Min. Order
Purity97.88%
Cas No410528-02-8
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	palovarotene
CAS No	410528-02-8
EC-No
Min. Order
Purity	97.88%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	palovarotene
Description	Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
In vivo	Palovarotene effectively hinders post-traumatic chondrogenesis, osteogenesis, and significantly reduces trauma-induced ectopic bone formation. Through oral administration (1 mg/kg/day for 14 days, starting from either the first or fifth day post-operation), this compound markedly decreases subcutaneous and intramuscular heterotopic ossification (HO) in mice, achieving a reduction of 50 to 60% in HO, irrespective of treatment initiation timing or infection presence. In a specific study, Acvr1cR206H/+ mice were divided into two groups: one treated with Palovarotene and the other with a vehicle control for 14 days beginning on the injury's first day. Comparative analysis using micro-CT and 3D imaging on the 14th day revealed that while significant HO tissue masses developed in the vehicle-treated group, Palovarotene-treated mice showed over an 80% reduction in HO formation, based on bone volume/total volume metrics.
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 5.5 mg/mL (13.27 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.41 mM), Sonication is recommended.
Keywords	Ro-3300074 \| Ro3300074 \| RetinoidReceptor \| Retinoid X receptors \| Retinoid Receptor \| Retinoic acid receptors \| RARγ \| RAR/RXR \| R-667 \| R667 \| palovarotene \| Inhibitor \| inhibit \| Autophagy
Inhibitors Related	Stavudine \| Aceglutamide \| Hemin \| Tamoxifen \| Cysteamine hydrochloride \| Guanidine hydrochloride \| Hydroxychloroquine \| Enzalutamide \| Paeonol \| Naringin \| Alginic acid \| Sildenafil citrate
Related Compound Libraries	Failed Clinical Trials Compound Library \| Bioactive Compound Library \| EMA Approved Drug Library \| Autophagy Compound Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Anti-Cancer Approved Drug Library \| FDA-Approved Drug Library \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library \| Anti-Cancer Active Compound Library \| Transcription Factor-Targeted Compound Library

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