pamaquine NEW

• DATA ITEMS CITED :

• 14

• MOLECULAR FORMULA :

• C19-H29-N3-O

• MOLECULAR WEIGHT :

• 315.51

• WISWESSER LINE NOTATION :

• T66 BNJ HO1 JMY1&3N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Unreported

• SPECIES OBSERVED :

• Human - man

• DOSE/DURATION :

• 7353 ug/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 68 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 12500 ug/kg

• TOXIC EFFECTS :

• Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Mammal - dog

• DOSE/DURATION :

• 20 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Mammal - cat

• DOSE/DURATION :

• 7500 ug/kg

• TOXIC EFFECTS :

• Behavioral - coma Blood - methemoglobinemia-carboxyhemoglobin

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Mammal - cat

• DOSE/DURATION :

• 5 mg/kg

• TOXIC EFFECTS :

• Behavioral - coma Blood - methemoglobinemia-carboxyhemoglobin

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Mammal - cat

• DOSE/DURATION :

• 5 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Behavioral - coma Blood - methemoglobinemia-carboxyhemoglobin

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 220 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 20 mg/kg

• TOXIC EFFECTS :

• Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 3500 ug/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Bird - chicken

• DOSE/DURATION :

• 57 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Bird - domestic

• DOSE/DURATION :

• 66 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Blood - methemoglobinemia-carboxyhemoglobin

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intramuscular

• SPECIES OBSERVED :

• Bird - domestic

• DOSE/DURATION :

• 33 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Blood - methemoglobinemia-carboxyhemoglobin

MUTATION DATA

• TYPE OF TEST :

• Mutation in microorganisms

• TEST SYSTEM :

• Bacteria - Salmonella typhimurium

• DOSE/DURATION :

• 1 mg/plate

• REFERENCE :

• MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 325,7,1994