| Name | Patamostat HCl |
| Description | Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis. |
| In vivo | In rats or rabbits, Patamostat (intravenous infusion) at doses of 0.03-0.3 mg/kg or 0.3-3.0 mg/kg, respectively, reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].In dogs with pancreatitis, Patamostat (intravenous infusion) at doses of 1.0-3.0 mg/kg reduces the increases of serum trypsin and lipase activities[1].In male Wistar rats, continuous infusion of Patamostat (2 mg/kg per h) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (111.38 mM), Sonication is recommended.
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| Keywords | Trypsin | SerineProtease | Serine Protease | Protease | Patamostat HCl | 114568-26-2 Free base | 114568-26-2 |
| Inhibitors Related | PMSF | AEBSF hydrochloride | Imidazole | Subtilisin | p-Aminobenzamidine dihydrochloride | Chymotrypsin | Proteinase K | Ac-Ala-OH | EDTA, Disodium Salt, Dihydrate | Trypsin | FOY 251 | Benzamidine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Protease Inhibitor Library | Multi-Target Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
