| Name | Pentamidine dihydrochloride |
| Description | Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent effective against various microorganisms, including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). It is a potent and selective inhibitor of protein tyrosine phosphatases and phosphatase of regenerating liver. Pentamidine dihydrochloride inhibits the parasite Leishmania infantum with an IC50 of 2.5 μM. |
| In vitro | Pentamidine at its therapeutic doses inhibited recombinant PRL phosphatases in vitro and inactivated ectopically expressed PRLs in NIH3T3 transfectants with an effective duration more than 24 h after a pulse cell treatment[3]. |
| In vivo | Pentamidine at a tolerable dose markedly inhibited the growth of WM9 human melanoma tumors in nude mice coincident with the induction of tumor cell necrosis and is capable of inactivating ectopically expressed PRL-2 in the cancer cells[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4.14 mg/mL (10.02 mM), Sonication is recommended.
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| Keywords | PTP1B | pneumonia | Pneumocystis | Phosphatase | Pentamidine dihydrochloride | Pentamidine | Parasite | MP-601205 Dihydrochloride | MP601205 Dihydrochloride | MP-601205 | MP601205 | MP 601205 Dihydrochloride | MP 601205 | Kidney | Inhibitor | inhibit | Fungal | DNA | cell-cycle | carinii | biosynthetics | Bacterial | arrest | antitumor | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | D(+)-Raffinose pentahydrate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Fenpyroximate | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Anti-Fungal Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |