| Name | Pevonedistat hydrochloride |
| Description | Pevonedistat hydrochloride (MLN4924 hydrochloride) is a selective and potent NEDD8 activating enzyme inhibitor (IC50: 4.7 nM) that induces apoptosis and cell cycle inhibition in cancer cells, and is used in the study of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Pelubiprofen has been used in the study of AML and MDS.) |
| In vitro | METHODS: To determine the effects of Pevonedistat hydrochloride on cell viability and clonogenic survival in four gastric cancer cell lines, cells were treated with different concentrations of Pevonedistat hydrochloride (0.01-4 μM) for 72 hours, followed by viability assays based on the ATP-lite assay.
RESULTS: Three of the gastric cancer cell lines were more sensitive to the growth inhibitory effects of Pevonedistat hydrochloride than GES-1 cells [3]. |
| In vivo | METHODS: To investigate the mechanism and therapeutic effects ofPevonedistat hydrochloride as an effective and selective NAE inhibitor.
RESULTS: Pevonedistat hydrochloride disrupted cullin-RING ligase-mediated protein turnover, leading to apoptosis in human tumor cells and inhibition of human tumor xenograft growth in mice[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.88 mM), Sonication is recommended.
DMSO : 80 mg/mL (166.67 mM), Sonication is recommended.
H2O : 8 mg/mL (16.67 mM), Sonication is recommended.
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| Keywords | NEDD8 | NAE | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
