| Name | PF-06424439 methanesulfonate |
| Description | PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2. |
| Animal Research | PF-06424439 methanesulfonate (i.v.; 1 mg/kg) shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].PF-06424439 methanesulfonate (p.o.; 60 mg/kg/day; for 3 days) reduces plasma TG and cholesterol levels and decreases nonsignificant in circulating lipids in mice (Ldlr-/-)[1]. |
| In vivo | PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 262.5 mg/mL (489.69 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (9.33 mM), Sonication is recommended. H2O : 99 mg/mL (184.68 mM), Sonication is recommended.
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| Keywords | PF-06424439 methanesulfonate | PF06424439 methanesulfonate | PF-06424439 | PF06424439 | PF 06424439 methanesulfonate | PF 06424439 | mono- acylglycerol acyltransferase | Inhibitor | inhibit | Diglyceride acyltransferase | Diacylglycerol acyltransferase | DGAT2 | Acyltransferase | acyl-CoA:cholesterol acyltransferase |
| Inhibitors Related | Alendronate sodium trihydrate | Serotonin hydrochloride | Serotonin | D(+)-Raffinose pentahydrate | 2,2'-Methylenebis(6-tert-butyl-4-methylphenol) | Risedronic Acid | Cyclandelate | Entacapone | CBHcy | 2-Furoic acid | Flopropione | Tolcapone |
| Related Compound Libraries | Bioactive Compound Library | Anti-Obesity Compound Library | Multi-Target Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Lipid Metabolism Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max |