| Name | Pheniramine maleate |
| Description | Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide. |
| In vivo | Pheniramine maleate binds to histamine H1 receptors, which inhibits the production of phospholipase A2 and the endothelium-derived relaxing factor NO. This leads to a reduction in the activation of guanylate cyclase due to NO deficiency, resulting in decreased levels of cyclic GMP (cGMP). Consequently, this suppresses the contraction of smooth muscle tissues, reduces capillary permeability, and diminishes histamine-induced allergic responses. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 65 mg/mL (182.37 mM), Sonication is recommended. Ethanol : 66 mg/mL (185.17 mM), Sonication is recommended. DMSO : 40 mg/mL (112.23 mM), Sonication is recommended.
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| Keywords | Tripoton | spinal block | sedative | Prophenpyridamine | Pheniramine Maleate | Pheniramine | lumbar puncture | Jurkat ALL | Inhibitor | inhibit | hypnotic | human T-cell acute lymphoblastic leukemia | HT | HistamineReceptor | Histamine Receptor | first-generation | CNS | central nervous system | CCRF-CEM | Ca2+ influx | BC3H-1 | Apoptosis | antipruritic | antiemetic | 5HTReceptor | 5HT Receptor |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |