| Name | Phenyl-β-D-glucopyranoside |
| Description | Phenyl-β-D-glucopyranoside (PHENYL-B-D-GLUCOPYRANOSIDE) is a component of Phellodendron amurense with anti-cancer and anti-inflammatory activities. |
| In vitro | Phenyl-β-D-Glucopyranoside Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated RAW 264.7 Cells. Phenyl-β-D-glucopyranoside not only inhibited nitric oxide (NO) production but also significantly inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) without inducing cytotoxicity. Phenyl-β-D-glucopyranoside also attenuated proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and other inflammation-related genes, such as IL-6 in a concentration-dependent manner. Furthermore, phenyl-β-D-glucopyranoside abolished increased adhesion, ninjurin 1 (Ninj1) expression, and matrix metalloproteinase (MMP) activity induced by endotoxin treatment. Finally, phenyl-β-D-glucopyranoside inhibited the nuclear translocation of nuclear factor-κB (NF-κB), which is one of the most important transcription factors involved in the inflammatory process. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : soluble DMSO : 60 mg/mL (234.15 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.8 mM), Sonication is recommended.
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| Keywords | Phenyl-β-D-glucopyranoside | PhenylβDglucopyranoside | Phenyl-beta-D-glucopyranoside | Phenyl β D glucopyranoside |
| Inhibitors Related | Sodium propionate | Ethyl palmitate | Kojic acid | Acetaminophen | Uridine | Fumaric acid | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | N,N-Dimethylacetamide | Trometamol | Magnesium sulfate |
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