| Name | Phloretin |
| Description | Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells. |
| In vitro | Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. [1] Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. [2] [3] Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets. [4] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 48 mg/mL (175.01 mM), Sonication is recommended.
DMSO : 80 mg/mL (291.68 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (12.03 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Sodium-dependent glucose cotransporters | SGLT2 | SGLT1 | SGLT | RJC-02792 | RJC02792 | Phloretin | NSC-407292 | NSC407292 | Inhibitor | inhibit | GLUT | Glucose transporter | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | GPCR Compound Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
United States
