| Name | PHY34 |
| Description | PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo. |
| In vitro | In HGSOC cell lines, PHY34 showed cytotoxicity with IC50 of 4 nM. Its IC50 values in MDA-MB-435 and MDAMB-231 cell lines were 23 nM and 5.2 nM, respectively. In OVCAR3 cells, 100 nM PHY34 increased the level of early and late apoptotic cells [1]. |
| In vivo | In the hollow fiber deflector, PHY34 significantly inhibited the growth of cancer cells; In the transplanted tumor model, PHY34 reduced the ovarian tumor load. The bioavailability of mice was 56.6% after intravenous injection of 0.6 mg/kg, intraperitoneal injection of 1.8 mg/kg or oral administration of 75 mg/kg PHY34, and 2.5% after oral administration. After oral administration, the systemic clearance (CL) was 194.1 L/hr/kg, which was nearly 40 times the liver blood flow of mice, indicating that PHY34 had significant extrahepatic clearance. After oral administration, PHY34 was rapidly absorbed, and Tmax was 0.25 hr [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF : 30 mg/mL (51.5 mM), Sonication is recommended.
DMSO:PBS (pH 7.2) (1:3) : 0.25 mg/mL (0.43 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 3.3 mg/mL (5.66 mM), Sonication is recommended.
DMSO : 90 mg/mL (154.49 mM), Sonication is recommended.
Ethanol : 10 mg/mL (17.17 mM), Sonication is recommended.
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| Keywords | PHY-34 | PHY34 | PHY 34 | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Bioactive Compound Library | Autophagy Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
