| Name | PI-103 Hydrochloride |
| Description | PI-103 Hydrochloride is a dual PI3K/Akt and mTOR inhibitor exhibiting nM-level inhibition of p110α, p110β, p110δ, p110γ, DNA-PK, mTORC1, and mTORC2. PI-103 induces autophagy, mitochondrial apoptosis, and cell cycle arrest, making it suitable for leukaemia research. |
| In vitro | PI-103 Hydrochloride exhibits anti-proliferative properties in a panel of Homo sapiens cancer cell lines (including prostate cancer, ovarian cancer, glioblastoma, and oropharyngeal squamous cell carcinoma) as well as in Homo sapiens umbilical vein endothelial cells [1].
PI-103 Hydrochloride demonstrates dose-dependent inhibition of proliferation in 37-31E and 37-31E-F3 cells. For 37-31E cells, proliferation growth can be inhibited by 50% when the PI-103 Hydrochloride concentration exceeds 100 nM, whereas the concentration required to achieve 50% inhibition in 37-31E-F3 cells is 40±2 nM. In the 37-31E-F3 cell line, the inhibitory effects of PI-103 Hydrochloride at concentrations of 50 nM and 100 nM are comparable to those achieved with 500 nM PI-103 Hydrochloride in the 37-31E cell line [4]. |
| In vivo | An orthotopic xenograft model was established by subcutaneously injecting 37-31E-F3 melanoma cells into immunocompetent FVB/N wild-type mice. Subsequent drug administration to the mice showed the following results: PI-103 Hydrochloride (10 mg/kg) significantly promoted in vivo tumor growth, while sorafenib (50 mg/kg) inhibited tumor growth. Compared with sorafenib monotherapy, the combined treatment with the two drugs did not exhibit additional benefits in terms of tumor inhibitory effect; furthermore, the tumor volume in the combined treatment group was even slightly larger than that in the sorafenib monotherapy group [4]. |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3 mg/mL (7.8 mM), Sonication and heating are recommended.
H2O : < 1 mg/mL (insoluble)
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| Keywords | PI-103 Hydrochloride | PI 103 Hydrochloride |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Ethyl linoleate | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | PI3K-AKT-mTOR Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library | ReFRAME Related Library | Kinase Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library |
United States
