Product Code: P032043
English Name: Piperacillin Impurity 43
English Alias: (2R,4S)-2-((R)-carboxy((R)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetamido)methyl)-5,5-dimethylthiazolidine-4-carboxylic acid
CAS No.: 64817-22-7
Molecular Formula: C₂₃H₂₉N₅O₈S
Molecular Weight: 535.57
Strict Structural Confirmation: Confirmed by NMR, HRMS, and elemental analysis with ≥98.5% purity (HPLC), meeting high requirements for Piperacillin impurity analysis.
Controllable Stability: Stored at -20℃ in the dark with a shelf life of 36 months; degradation rate <1% in acetonitrile-water solution within 3 months.
Antibiotic Quality Research: Used for impurity detection in Piperacillin API and formulations, complying with USP, EP, and other pharmacopoeial standards for β-lactam antibiotics.
Methodology Validation: Serves as a reference standard for developing impurity detection methods, verifying HPLC specificity and sensitivity (LOQ 0.1 μg/mL).
Piperacillin, a broad-spectrum semi-synthetic penicillin, may generate Impurity 43 from side chain condensation or piperazine ring oxidation. With complex structure and multiple chiral centers, this impurity may affect the drug's antibacterial activity and safety. As antibiotic impurity control standards improve, studying such complex impurities is key to ensuring drug quality.
Detection Technology: HPLC-UV (220nm) with C18 column (5μm) and phosphate buffer-acetonitrile gradient elution, achieving resolution >2.0 and LOQ 0.5 μg/mL.
Formation Mechanism: Results from side reactions between Piperacillin side chain and 4-ethyl-2,3-dioxopiperazine intermediates; optimizing acylation reaction pH (7.0-7.5) reduces impurity generation by >50%.
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
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