| Name | Pivagabine |
| Description | Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain. |
| Animal Research | Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions, reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex[2]. |
| In vivo | Pivagabine (CXB 722) (200 mg/kg; i.p.; administered twice daily for 4 days and 1 hour before euthanasia on the 5th day) prevents foot-shock stress-induced changes in CRF concentration in both brain regions[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (240.33 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (10.68 mM), Sonication is recommended.
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| Keywords | γ-Aminobutyric acid Receptor | shock | psychoactive | Pivagabine | neuromodulatory | Inhibitor | inhibit | Gamma-aminobutyric acid Receptor | GABAReceptor | GABAA | GABA Receptor | foot | factor | derivative | CXB722 | CXB 722 | corticotropin-releasing | blood-brain | barrier |
| Inhibitors Related | Valproic acid sodium salt | p-Hydroxybenzaldehyde | Urethane | Baicalin | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | (-)-α-Pinene | Nipecotic acid | Methionine | Dihydromyricetin | Isoflurane |
| Related Compound Libraries | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
United States
