Pivalic acid 99%min
purpose
1. It is used as a raw material for producing TBPP as an initiator for olefin polymerization, as well as a stabilizer for producing polyvinyl chloride and a raw material for spices. Used for manufacturing pharmaceuticals, adhesives, initiators, fragrances, and stabilizers for polyvinyl chloride.
When studying the application of Raney nickel in asymmetric hydrogenation reactions using acid catalyzed asymmetric reduction, it was found that products with higher optical purity can be obtained using neovaleric acid as a catalyst. The reduction of 2-octanone to 2-octanol under the action of Raney nickel modified with tartaric acid and sodium bromide can be achieved by using a THF/carboxylic acid mixture as the reaction medium, which can improve optical purity, while neovaleric acid can reach the maximum value. When using modified Raney nickel to catalyze the hydrogenation reduction of various methyl ketones in the presence of neovaleric acid, corresponding (S) - RCH (OH) Me compounds with high optical purity can be obtained. Acid catalyzed rearrangement uses propionic acid as a catalyst, with o-methoxyphenol and triethyl orthoacrylate refluxing in benzene. The yield of the cyclization product of the Clayson rearrangement is only 50%, as the catalyst is esterified. And using neovaleric acid with greater steric hindrance as a catalyst, high yields can be achieved（
Equation 1). In the study of region selective protonation of allyl enols, neovaleric acid exhibits strong selectivity, -8
At 0 ° C, the intermediate enol can be specifically protonated at the C-2 position by quenching with neovaleric acid（
Equation 2). The decarboxylation reaction of carboxylic acid catalyzed by silver tert butyl persulfate obtained through oxidative decarboxylation can generate alkyl radicals, which can be used for alkylation of aromatic bases. During this process, neovaleric acid can serve as a donor for tert butyl, and 2-tert butyl quinoline is regioselectively synthesized through this method（
Equation 3). Preparation of 2-tert butylpyrimidine 2-tert butylpyrimidine is a precursor of insecticide 2-tert butylpyrimidine thiophosphate, which can be synthesized from butylamine and neovaleric acid. In the presence of ketones or enols γ- Introducing other nucleophilic groups, such as using TBSN
3. The interaction between t-BuCO2H and Et3N with ketones can γ Introducing azide groups (Equation 4,
Equation 5).
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