| Name | PNU-282987 |
| Description | PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). |
| Kinase Assay | Kinase inhibition assays : Kinase inhibition is measured by the use of radiometric assays conducted by Kinase Profiler service. Briefly, in the presence or absence of SKLB1002, VGFR2 (5–10 mU) is incubated in 25-μL reaction solution containing 8 mmol/L 3-(N-morpholino)propanesulfonic acid (MOPS), pH 7.0, 0.2 mmol/L EDTA, 0.33 mg/mL myelin basic protein, 10 mmol/L Mg acetate, and γ-[33P]ATP. After incubation for 40 minutes at room temperature, the reaction is stopped and 10 μL of the reaction solution is then spotted onto a P30 filtermat and washed 3 times for 5 minutes in 75 mmol/L phosphoric acid and once in methanol prior to scintillation counting. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 25 mg/mL (83 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 1.67 mg/mL (5.54 mM), Sonication is recommended.
DMSO : 250 mg/mL (829.99 mM), Sonication is recommended.
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| Keywords | α7 nAChR | PNU-282987 | PNU282987 | PNU 282987 | Nicotinic acetylcholine receptors | nAChR | Inhibitor | inhibit |
| Inhibitors Related | Adiphenine hydrochloride | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Urethane | Hexamethonium Bromide | 1,8-Cineole | Adenine | Mitotane | N,N-Dicyclohexylcarbodiimide | Arecoline | Cinchonidine |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library | Ion Channel Targeted Library | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library |
United States
