| Name | Polygodial |
| Description | Polygodial (Tadeonal) is an antifungal potentiator and an antibiotic, particularly against Saccharomyces cerevisiae, Candida utilis, and Sclerotinia libertiana. |
| In vitro | When tested on S. cerevisiae, polygodial proved to be fungicidal rather than fungistatic. When the cells of S. cerevisiae are treated in vitro with polygodial for 10 min, the cell membrane becomes severely damaged, and many vesicles, possibly formed from the fragmented cell membrane, can be observed within the cytoplasm[1]. |
| In vivo | Polygodial (0.1 to 10 mg kg(-1), i.p.) produced significant inhibition of acetic acid, kaolin and zymosan-induced writhing in mice, being about 14 to 27-fold more potent than the hydroalcoholic extract at the ID50 level[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 65 mg/mL (277.39 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.53 mM), Sonication is recommended.
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| Keywords | Polygodial | Poligodial | Inhibitor | inhibit | Fungal | Antifungal,Potentiator,sesquiterpene,anti-hyperalgesic | Antifungal |
| Inhibitors Related | Calcium Propionate | Dehydroacetic acid sodium | Potassium gluconate | D-Gluconic acid (solution) (50% in H2O) | Sulfacetamide sodium | Benzyl propionate | Terbinafine hydrochloride | Sodium formate | Magnesium acetate tetrahydrate | Geraniol | L-Citronellol | Benzimidazole |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Rare Natural Product Library | Anti-Fungal Compound Library | Antibiotics Library | Natural Product Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Bioactive Lipid Compound Library | Anti-Infection Compound Library |