| Name | Praeruptorin B |
| Description | Praeruptorin B (Praeruptorin D), a compound found in the roots of Peuced, is an inhibitor of sterol regulatory element-binding proteins (SREBPs) that attenuates the metastatic ability of human renal cancer cells by targeting CTSC and CTSV expression, and can be used in the study of osteoporosis. |
| In vitro | Praeruptorin B inhibited the activity of SREBPs and reduced intracellular lipid levels, and significantly down-regulated the expression of SREBP-1c and SREBP-2.Praeruptorin B potently reduced SRE-luciferase activity and the effect was dose-dependent.[1] |
| In vivo | Mice treated with 50 mg/kg Praeruptorin B weighed significantly less than those treated with the vector, although they were still heavier than mice fed regular chow, suggesting that Praeruptorin B ameliorates diet-induced obesity (DIO). Staining results showed that Praeruptorin B-treated mice exhibited less lipid accumulation than vector-treated mice. Elevated fasting blood glucose and insulin levels in high-fat diet-fed mice were significantly reduced by Praeruptorin B. The results showed that the elevated fasting blood glucose and insulin levels in Praeruptorin B-treated mice were significantly reduced. [1] |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2 mg/mL (4.69 mM), Sonication is recommended.
DMSO : 20 mg/mL (46.9 mM), Sonication is recommended.
|
| Keywords | T6S1423 | SREBPs | Praeruptorin B | Inhibitor | inhibit | Fatty Acid Synthase (FASN) |
| Inhibitors Related | 2-Octanone | Betulin | Ezetimibe | α-Lipoic Acid sodium | Maltitol | Coenzyme A | Pyrazinamide | A-769662 | trans-Chalcone | Orlistat | L-Carnitine | Lycorine |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Chinese Pharmacopoeia Natural Product Library | Natural Product Library | Natural Product Library for HTS | Metabolism Compound Library | Lipid Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Ancient Chinese Classical Formulas Compound Library |
United States
