| Name | Pravastatin sodium |
| Description | Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM. |
| In vitro | Pravastatin (30 mg/kg/day) reduced malnutrition-induced lesions by 34%. In female Wistar rats exposed to radiation, which presented with decreased CCN2 levels, Pravastatin (30 mg/kg/day) could restore muscle structure. A single dose of 40 mg of Pravastatin lowered cholesterol synthesis by 62% in monocytes from healthy individuals and by 47% in patients with hypercholesterolemia. Moreover, treatment with Pravastatin (40 mg/day for 8 weeks) in hypercholesterolemic patients increased LDL degradation by 57% while inhibiting cholesterol synthesis by 55%. |
| In vivo | In murine peritoneal macrophages (MPM), the J-774 A.1 macrophage-like cell line, and human monocyte-derived macrophages (HMDM), Pravastatin exhibits a dose-dependent inhibition of cholesterol synthesis. Upon LDL addition, concentrations of Pravastatin below 0.19 μg/mL enhance the esterification of cellular cholesterol, whereas levels below 100 μg/mL suppress esterification. At less than 0.5 mM, Pravastatin attenuates the Rho/ROCK pathway activity in human ileal and colonic transplants, reducing CCN2 mRNA levels. Pravastatin at concentrations less than 1 mM also induces the inhibition of CCN2 in primary human smooth muscle cells. In all cases, Pravastatin at less than 0.5 mM reduces the mRNA levels of type I collagen and fibronectin. Pravastatin facilitates vasodilation in aortic rings, achieving 62.8% endothelium-dependent relaxation at 10 μM after 8 minutes. Pravastatin-Na at 10 μM inhibits sterol synthesis with 50% greater efficacy than in peripheral blood mononuclear cells. In bovine aortic endothelial cells, Pravastatin at less than 10 μM stimulates NOS activity and NO release within 10 minutes, with L-arginine further enhancing NO production in response to Pravastatin. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 44.7 mg/mL (100.11 mM), Sonication is recommended.
DMSO : 45 mg/mL (100.78 mM), Sonication is recommended.
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| Keywords | Pravastatin sodium | Pravastatin | Inhibitor | inhibit | HMGCR | HMGCoAReductase | HMG-CoA Reductase (HMGCR) | HMG-CoA reductase | HMGCoA Reductase | Ferroptosis | CS-514 | CS514 | CS 514 | Autophagy |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | L-Glutamic acid | Taurine | Valproic Acid | Paeonol | L-Cystine | L-Glutamine | Naringin | Gefitinib |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Microbial Natural Product Library | Natural Product Library for HTS | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Metabolism Compound Library | Lipid Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
