| Name | Pregnenolone Carbonitrile |
| Description | Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A. |
| In vitro | Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults[4]. |
| In vivo | In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels[2]. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA[3]. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression[4]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (87.85 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | PXR | Pregnenolone Carbonitrile | Pregnenolone 16α-carbonitrile | Pregnenolone 16alpha-carbonitrile | Pregnenolone 16a-carbonitrile | P4503A | orally | Inhibitor | inhibit | Cytochrome P450 | cytochrome | CYPs | CYP3A | 5-Pregnen-3b-ol-20-one-16a-carbonitrile | 5-Pregnen-3beta-ol-20-one-16alpha-carbonitrile |
| Inhibitors Related | Tebuconazole | Oxadiazon | Musk ketone | Naringin dihydrochalcone | Ipriflavone | Benzyl alcohol | Sudan IV | Naringin | Chlorzoxazone | Dibenzothiophene | Clarithromycin | Memantine hydrochloride |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Multi-Target Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Bioactive Lipid Compound Library | Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Human Metabolite Library |