| Name | Pregnenolone monosulfate sodium |
| Description | Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors. |
| In vitro | Pregnenolone monosulfate sodium does not alter agonist binding, but only agonist efficacy. Pregnenolone monosulfate sodium may act as a signal-specific negative allosteric modulator that occupies a site distinct from that occupied by the orthosteric ligand. When slices were pretreated with 100 nM Pregnenolone monosulfate sodium, the effects of THC were significantly attenuated (15.1 ± 1.8% inhibition). These effects may be due to Pregnenolone monosulfate sodium's presynaptic actions. Thus, Pregnenolone monosulfate sodium prevented the THC-induced increase in paired-pulse ratio but did not alter the amplitude or decay time of miniature EPSCs. [1] |
| In vivo | Pregnenolone monosulfate sodium (2, 4 mg/kg) injected before each dose reduced WIN 55,212-2 intake and lowered breakpoints in a progressive ratio schedule.
Pregnenolone monosulfate sodium (2-6 mg/kg) blocked THC-induced food intake in Wistar rats and C57BL/6N mice and attenuated THC-induced memory impairment in mice, but it did not modify these behaviors by itself [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (191.15 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (7.88 mM), Sonication is recommended.
H2O : 2 mg/mL (4.78 mM), Sonication is recommended.
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| Keywords | Pregnenolone monosulfate sodium salt | Pregnenolone monosulfate sodium | Human Endogenous Metabolite | CB1 | 3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt | 3b-Hydroxy-5-pregnen-20-one monosulfate sodium | 3beta-Hydroxy-5-pregnen-20-one monosulfate sodium |
| Inhibitors Related | Sucrose | Aceglutamide | Hemin | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Histone Modification Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Neurotransmitter Receptor Compound Library | Multi-Target Compound Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Ion Channel Targeted Library | GPCR Compound Library | Anti-Cancer Compound Library | Human Metabolite Library |
United States
