| Name | Procyanidin A1 |
| Description | Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells. |
| In vitro | We found that a peanut-skin extract (PSE) inhibits the degranulation induced by antigen stimulation of rat basophilic leukemia (RBL-2H3) cells. A low-molecular-weight fraction from PSE, PSEL, also had inhibitory activity against allergic degranulation. A main polyphenol in PSEL was purified by gel chromatography and fractionated by YMC-gel ODS-AQ 120S50 column. Electrospray ionization mass spectrometry (ESI-MS) analysis of the purified polyphenol gave m/z 599 [M+Na]?. Based on the results of 1H-NMR, 13C-NMR spectra, and optical rotation analysis, the polyphenol was identified as Procyanidin A1. It inhibited the degranulation caused by antigen stimulation at the IC50 of 20.3 μM. Phorbol-12-myristate-13-acetate (PMA) and 2,5,-di(tert-butyl)-1,4-hydroquinone (DTBHQ)-induced processes of degranulation were also inhibited by Procyanidin A1[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 140 mg/mL (242.84 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.00 mg/mL (3.47 mM), Sonication is recommended.
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| Keywords | Protein kinase C | Procyanidin A-1 | Procyanidin A1 | Procyanidin A 1 | Proanthocyanidin A-1 | Proanthocyanidin A 1 | PKC | LDL | Inhibitor | inhibit | CalciumChannel | Calcium Channel |
| Inhibitors Related | Quadrol | Tricaine methanesulfonate | Nisoldipine | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | α-Vitamin E | Taurine | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Kinase Inhibitor Library | Natural Product Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Ion Channel Targeted Library | Ancient Chinese Classical Formulas Compound Library | TGF-beta/Smad Compound Library |
United States
