| Name | Procyanidin B2 |
| Description | Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway. |
| Animal Research | Streptozotocin-induced diabetic rats were fed with either 3% cinnamon or 0.002% Procyanidin B2(PCB2)-fraction in diet for 12weeks. Biochemical analysis of blood and urine was performed at the end of experiment. Evaluation of glomerular markers that serve as indicators of renal function was done by immunohistochemistry, immunoblotting and qRT-PCR. Supplementation of diabetic rats with cinnamon and PCB2-fraction prevented glycation mediated RBC-IgG cross-links and HbA1c accumulation in diabetes rats. Cinnamon and PCB2-fraction also inhibited the accumulation of N-carboxy methyl lysine (CML), a prominent AGE in diabetic kidney[2]. |
| In vitro | Procyanidin B2 exerts both antioxidant and pro-oxidant properties by interacting with H2O2 and metal ions[1]. |
| In vivo | Procyanidin B2 from cinnamon inhibited AGE accumulation in diabetic rat kidney and ameliorated AGE mediated pathogenesis of DN[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 83.33 mg/mL (144.04 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.46 mM), Sonication is recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Procyanidin B-2 | Procyanidin B2 | Procyanidin B 2 | Proanthocyanidin B-2 | Proanthocyanidin B 2 | NLRP3 | Inhibitor | inhibit |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | Copper Sulfate Pentahydrate | L-Ascorbic acid sodium salt | Dimethyl phthalate | Diisononyl phthalate |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
United States
