| Name | Progesterone |
| Description | Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. |
| In vitro | Twenty-one days after dorsal medial thalamic nuclei damage, rats treated with progesterone exhibited reduced neuronal degeneration. In female 3xTg-AD mice, progesterone negated the advantageous effects against Abeta accumulation, yet it did not affect behavioral performance. During the Morris water maze spatial navigation task, progesterone-treated rats demonstrated less impairment compared to control rats. |
| In vivo | Progesterone drives a series of events in which luminal cells may furnish basal cells with Wnt4 and RANKL signals, which in turn respond by upregulating homologous receptors, transcriptional targets, and markers of the cell cycle. Progesterone exhibits a biphasic effect on the proliferation of breast cancer cells; it stimulates growth during the initial cell cycle and subsequently impedes cell progression at the G1/S phase. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 31.5 mg/mL (100.17 mM), Sonication is recommended.
Methanol : Insoluble
DMSO : 47.48 mg/mL (150.99 mM), Sonication and heating are recommended.
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| Keywords | κ-opioid receptor | progestogenReceptor | progestogen Receptor | ProgesteroneReceptor | Progesterone Receptor | Progesterone | OpioidReceptor | Opioid Receptor | NR3C3 | Inhibitor | inhibit | EstrogenReceptor | Estrogen Receptor | ER | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Neurodegenerative Disease Compound Library | Miao medicine Compound Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | Bitter Compound library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
United States
