| Name | Propylparaben |
| Description | Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial agent, preservative, and flavoring agent. |
| Cell Research | Experimental conditions were as follows: a) basal recordings during which artificial cerebrospinal fluid (ACSF) (in mM: NaCl,125; KCl, 3; Na2HPO4, 1.25; NaHCO3, 25; MgCl2, 2; CaCl2, 2-D-(+)-glucose, 10; gassed with a mixture of 95% O2–5% CO2) was perfused; b) ACSF plus Propylparaben(PPB) (500 μM); c) 4-AP (100 μM) in Mg2+free-ACSF; d) 4-AP in Mg2+free-ACSF plus vehicle (dimethyl sulfoxide, DMSO at 0.04%); e) 4-AP in Mg2+free-ACSF plus drugs (phenytoin (PHT), 200 μM; PPB, 200 and 7500 μM). Each experimental condition lasted for 10 min. The onset of 4-AP-induced epileptiform activity was considered when bursts of 5 of more consecutive action potentials (APs) were present. The number of APs and excitatory postsynaptic potentials (EPSPs) greater than 1 mV and less than 10 mV of amplitude were quantified during periods of 5 min for each experimental condition[2] |
| In vitro | Propylparaben(PPB) suppressed the epileptiform activity in registered neurons.?This effect disappeared when PPB was removed from the solution of incubation.?PPB exerts an antiepileptic effect on CA1 pyramidal neurons in vitro.?Therefore, PPB may represent an effective antiepileptic compound[1]. propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (332.96 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (11.1 mM), Sonication is recommended.
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| Keywords | Propylparaben | Inhibitor | inhibit | Human Endogenous Metabolite | EndogenousMetabolite | Endogenous Metabolite | Bacterial | Apoptosis |
| Inhibitors Related | Sucrose | Neomycin sulfate | Aceglutamide | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Glycerol | Thymidine | Gluconate Calcium | Dimethyl sulfoxide | Sodium bicarbonate |
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United States
