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ChemicalBook Product Catalog Analytical Chemistry Standard Chinese medicine standards Protosappanin A

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Protosappanin A NEW

$85.00 1mg

$217.00 5mg

$353.00 10mg

Min. Order
Purity99.82%
Cas No102036-28-2
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	Protosappanin A
CAS No	102036-28-2
EC-No
Min. Order
Purity	99.82%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	Protosappanin A
Description	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.
In vitro	Protosappanin A (PsA) and Protosappanin B (PsB) were identified from Sappan Lignum extracts. They showed activity against both S. aureus and MRSA with MIC or MIC50 at 64 (PsA) and 128 (PsB) mg/L alone. When they were used in combination with antibiotics, they showed the best synergy with amikacin and gentamicin with MIC50 (mg/L) of amikacin reduced more significantly from 32 to four (with PsA) and eight (with PsB), and the fractional inhibitory concentration index (FICI) ranged between 0.078 and 0.500 (FICI50 = 0.375). Moreover, the resistance of MRSA towards amikacin and gentamicin could be reversed by the Clinical and Laboratory Standards Institute criteria. The combined bactericidal mode could as well be synergy. PsA and PsB showed very low cytotoxicity in comparison with their promising activity against MRSA[1].
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 225 mg/mL (826.45 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (18.37 mM), Sonication is recommended.
Keywords	TNF-α \| TLR \| STAT \| ROS \| Protosappanin A \| NOSynthase \| NO Synthase \| NO \| NF-κB \| NFκB \| NF-kB \| NFkB \| NADPH-oxidase \| NADPHoxidase \| Janus kinase \| JAK \| IκB \| Inhibitor \| inhibit \| ILReceptor \| IL Receptor \| IKK \| IkB/IKK \| IkB \| IFN-γ \| HIVProtease \| HIV-1 IN \| HIV-1 \| HIV Protease
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