| Name | Prunetin |
| Description | 1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 125 mg/mL (439.74 mM), Sonication is recommended.
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble
10% DMSO+90% Saline : 2.5 mg/mL (8.79 mM), Sonication is recommended.
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| Keywords | rhinitis | Prunetin | NF-κB | NFκB | NF-kB | NFkB | nasal | liver | Inhibitor | inhibit | inflammatory | ERK | epithelial | cytokine | allosteric | allergic | ALDH | Aldehyde Dehydrogenase (ALDH) |
| Inhibitors Related | Urea | Sodium propionate | Gum arabic | Kojic acid | Uridine | Fumaric acid | Benzyl alcohol | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | N,N-Dimethylacetamide | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Kinase Inhibitor Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Flavor Natural Product library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
