| Name | PRX-07034 hydrochloride |
| Description | PRX-07034 hydrochloride is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 hydrochloride is both a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors. |
| In vitro | PRX-07034 is a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist with 100-fold selectivity over 68 other GPCRs, ion channels, and transporters, except for D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors. It demonstrated antagonist activity in cyclic AMP quantification (IC(50) = 19 nM) without affecting basal levels and showed no agonist activity up to 10 μM. At doses of 1 and 3 mg/kg, PRX-07034 significantly enhanced delayed spontaneous alternation and switching between place and response strategies, but did not affect initial learning of place or response discrimination. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.04 mM), Sonication is recommended.
DMSO : 10 mg/mL (20.39 mM), Sonication is recommended.
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| Keywords | working | PRX-07034 Hydrochloride | PRX-07034 | PRX07034 | PRX 07034 | memory | flexibility | cognitive | 5HTReceptor | 5-HT6 | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | 1,8-Cineole | Dopamine hydrochloride | Cloperastine hydrochloride | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine | Doxepin hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library | Anti-Cancer Drug Library |
United States
