| Name | Punicalagin |
| Description | Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes. |
| In vitro | METHODS: Human cervical cells ME-180 were treated with Punicalagin (10-100 µM) for 24 h. Cell viability was measured by MTT assay.
RESULTS: Punicalagin showed significant concentration-dependent cytotoxicity against ME-180 cells. The cell viability of Punicalagin-treated cells was reduced by approximately 80% compared to control cells. [1]
METHODS: Human cervical cancer cells, the HeLa, were treated with Punicalagin (25-100 µM) for 36 h. The cell cycle was detected by Flow cytometry.
RESULTS: The number of G1-phase cells increased significantly after 36 h of Punicalagin treatment. [2] |
| In vivo | METHODS: To study the effects on MTX-induced hepatotoxicity in mice, Punicalagin (25-50 mg/kg, 0.5% CMC) was administered orally to Swiss albino mice once daily for ten days, followed by a single dose of MTX (20 mg/kg) injected intraperitoneally on the seventh day.
RESULTS: Punicalagin significantly attenuated MTX-induced elevation of serum aminotransferases, ALP, and LDH, as well as hepatic oxidative stress measures, and enhanced hepatic antioxidant defense. In MTX-induced mouse liver, Punicalagin inhibited oxidative damage, inflammation and apoptosis and upregulated Nrf2. [3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL (92.19 mM), Sonication is recommended.
DMSO : 260 mg/mL (239.69 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (4.61 mM), Sonication is recommended.
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| Keywords | SARS-CoV | SARSCoV | SARS coronavirus | Punicalagin | Pomegranate | polyphenol | Inhibitor | inhibit | ingredient | Hepatitis B virus | HBV | Antioxidant | anti-inflammatory | anticancer |
| Inhibitors Related | Molnupiravir | Silymarin | Hydroxychloroquine | Lamivudine | Ritonavir | Chloroquine phosphate | Tenofovir Disoproxil Fumarate | α-Cyclodextrin | Thiamine hydrochloride | Dexamethasone | Nicotinamide | Tenofovir |
| Related Compound Libraries | Polyphenolic Natural Product Library | Bioactive Compound Library | Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
United States
