| Name | Purpurogallin |
| Description | Purpurogallin, a naturally occurring phenol extracted from Quercus spp. plants, exhibits potent xanthine oxidase inhibitory activity (IC50: 0.2 μM) and also possesses antioxidant and anti-inflammatory effects. |
| In vitro | Purpurogallin (100 μM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells. Purpurogallin (50 or 100 μM; 7 or 25 hours; BV2 murine microglial cells) treatment decreases the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells[1]. |
| In vivo | By the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression, Purpurogallin (100-400?μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect [2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 125 mg/mL (567.72 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (18.17 mM), Sonication is recommended.
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| Keywords | XanthineOxidase | Xanthine Oxidase | Purpurogallin | Inhibitor | inhibit |
| Inhibitors Related | Allopurinol | 2,6-Dihydroxyacetophenone | Phytic acid dodecasodium salt hydrate | Baicalein | Febuxostat | Phytic acid | Benzbromarone | 4-Hydroxyacetophenone | Oxypurinol | 4-Nitrocinnamic acid | Xanthine oxidase-IN-1 | Luvadaxistat |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Viral Compound Library | Inhibitor Library | Cosmetic Ingredient Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Oxidation-Reduction Compound Library |
United States
