| Name | PXS-5120A |
| Description | PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity. |
| In vitro | PXS-5120A is >300-fold selective for LOXL2 (Ki of 83 nM; pIC50 of 8.4) over LOXL (pIC50 of 5.8)[1]. PXS-5120A inhibits recombinant human LOXL2, human fibroblast LOXL2, recombinant mouse LOXL2, recombinant rat LOXL2, collagen oxidation assay, recombinant human LOXL3 and recombinant human LOXL4(IC50s of 5 nM, 9 nM, 6 nM, 6 nM, 13 nM, 16 nM and 280 nM, respectively)[1]. |
| In vivo | In mice, PXS-5129A is readily absorbed following oral gavage, and rapidly hydrolyzed to release PXS-5120 (free base) in vivo, affording plasma concentrations well above the LOXL2 IC50 (6 nM) for a prolonged period (>6 h), while remaining well below the IC50 for LOX throughout[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (103.74 mM), Sonication is recommended.
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| Keywords | PXS-5120A | PXS5120A | PXS 5120A | MonoamineOxidase | Monoamine Oxidase | MAO | LOXL3 | LOXL2 | Inhibitor | inhibit |
| Inhibitors Related | Safinamide | Indazole | 1,4-Naphthoquinone | Paeonol | Hydroxylamine hydrochloride | Isatin | Methylene Blue | Methylene Blue trihydrate | β-Aminopropionitrile | Aminoacetone hydrochloride | D-(-)-Quinic acid | Amitraz |
| Related Compound Libraries | Mitochondrial Membrane Protein-Targeted Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Antidepressant Compound Library | Neuronal Signaling Compound Library | Multi-Target Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Fibrosis Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |