Pyridoxine hydrochloride NEW

• MOLECULAR FORMULA :

• C8-H11-N-O3.Cl-H

• MOLECULAR WEIGHT :

• 205.66

• WISWESSER LINE NOTATION :

• T6NJ B1 CQ D1Q E1Q &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 4 gm/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 3 gm/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 530 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 5500 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 2450 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 660 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Mammal - dog

• DOSE/DURATION :

• >500 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Mammal - cat

• DOSE/DURATION :

• 1 gm/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Mammal - cat

• DOSE/DURATION :

• 560 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intramuscular

• SPECIES OBSERVED :

• Mammal - cat

• DOSE/DURATION :

• 500 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 464 mg/kg

• TOXIC EFFECTS :

• Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Bird - pigeon

• DOSE/DURATION :

• 145 mg/kg

• TOXIC EFFECTS :

• Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Mammal - dog

• DOSE/DURATION :

• 21400 mg/kg/15W-I

• TOXIC EFFECTS :

• Spinal Cord - demyelination Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 2 mg/kg

• SEX/DURATION :

• female 38 week(s) after conception

• TOXIC EFFECTS :

• Reproductive - Maternal Effects - postpartum

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intramuscular

• DOSE :

• 2 mg/kg

• SEX/DURATION :

• female 38 week(s) after conception

• TOXIC EFFECTS :

• Reproductive - Maternal Effects - postpartum

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 8040 ug/kg

• SEX/DURATION :

• female 14 week(s) pre-mating - 12 day(s) post-birth

• TOXIC EFFECTS :

• Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 4 gm/kg

• SEX/DURATION :

• female 6-15 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• DOSE :

• 15 gm/kg

• SEX/DURATION :

• male 2 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - testes, epididymis, sperm duct

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• DOSE :

• 7500 mg/kg

• SEX/DURATION :

• male 6 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• DOSE :

• 15 gm/kg

• SEX/DURATION :

• male 6 week(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

• TYPE OF TEST :

• Sister chromatid exchange

• TEST SYSTEM :

• Human Lymphocyte

• DOSE/DURATION :

• 2 mg/L

• REFERENCE :

• MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,175,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3950 No. of Facilities: 1955 (estimated) No. of Industries: 8 No. of Occupations: 39 No. of Employees: 57249 (estimated) No. of Female Employees: 35753 (estimated)