| Name | Pyridoxylamine |
| Description | Pyridoxylamine (pyridoxamine) is an inhibitor of advanced glycation end production (AGEs) and lipoxidation end products (ALEs). |
| In vitro | Pyridoxylamine (PM) is a member of the B6 vitamer family,and is a potent scavenger of reactive carbonyls, inhibiting the late stages of glycation reactions that lead to AGE formation[1]. |
| In vivo | In STZ diabetic rats, Pyridoxylamine inhibited the formation of CML and CEL and the cross-linking of skin collagen, ultimately inhibiting the development of nephropathy. Pyridoxamine does not appear to act as an antioxidant because it does not inhibit lipid peroxidation. However, it prevents modification of proteins by lipid peroxidation products, including inhibition of the formation of adducts of malondialdehyde and 4-hydroxynonenal on proteins in Zucker rats [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (11.89 mM), Sonication is recommended.
DMSO : 65 mg/mL (386.47 mM), Sonication is recommended.
H2O : 6.25 mg/mL (37.16 mM), Sonication is recommended.
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| Keywords | Pyridoxylamine | Inhibitor | inhibit | Human Endogenous Metabolite | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Selected Plant-Sourced Compound Library | Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | Microbial Natural Product Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Human Metabolite Library |
United States
