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ChemicalBook Product Catalog QF0301B

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QF0301B NEW

$700.00 1mg

$1800.00 5mg

Min. Order
Purity99.16%
Cas No149247-12-1
Supply Ability10g
Update time2025-06-18

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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United States

United States

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Chemical Properties

Product Name	QF0301B
CAS No	149247-12-1
EC-No
Min. Order
Purity	99.16%
Supply Ability	10g
Release date	2025/06/18

Product Introduction

Bioactivity

Name	QF0301B
Description	QF0301B is a potent α1-adrenergic receptor antagonist with inhibitory effects on α2-adrenergic receptors, 5-HT2A and histamine H1 receptors.
In vitro	QF0301B exhibits marked α1-adrenoceptor blocking activity in isolated rubbed rat aorta rings, with a pA2 value of 9.00±0.12. In electrically stimulated rat vas deferens, QF0301B reverses and competitively antagonizes the inhibitory action produced by clonidine. Additionally, it inhibits the force and rate of contraction in rat isolated atria (pA2=5.91±0.43), competitively antagonizes the contractile effect of 5-HT in rat aorta (pA2=6.75±0.06) and in rat stomach fundus (pA2=7.13±0.48), as well as the contractions induced by histamine in isolated guinea pig longitudinal ileal muscle (pA2=7.40±0.40). QF0301B shows noncompetitive low action in 5-HT3, muscarinic, and nicotinic receptors, as well as Ca2+ antagonist[1].
In vivo	QF0301B (0.1-0.2 mg/kg iv) induces a significant and prolonged decrease in mean arterial blood pressure accompanied by bradycardia. It does not significantly alter the cardiovascular effects of either 5-hydroxytryptamine (serotonin, 5-HT, 75 mg/kg iv) or the selective α2-adrenoceptor agonist B-HT 920 (0.2 mg/kg iv). However, QF0301B markedly inhibits the hypertensive effect of noradrenaline (5 mg/kg iv), a nonselective α-adrenergic receptor agonist[1].
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Keywords	α2-adrenergic receptor \| α1-adrenergic receptor \| QF-0301B \| QF0301B \| AdrenergicReceptor \| Adrenergic receptor \| Adrenergic Receptor \| 5HTReceptor \| 5-HT2A \| 5HT Receptor
Inhibitors Related	Alverine citrate \| Dapoxetine hydrochloride \| Clozapine N-Oxide \| Octopamine hydrochloride \| Dexmedetomidine hydrochloride \| D-Menthol \| Amitriptyline hydrochloride \| Isoprenaline hydrochloride \| Trazodone hydrochloride \| Mianserin hydrochloride \| Fluoxetine hydrochloride \| Cinchonidine

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