| Name | Qingyangshengenin B |
| Description | Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish. |
| In vitro | Otophylloside B (Ot B)?could modestly extend the lifespan of C. elegans, delay the age-related decline of body movement and improve the stress resistance.?Further investigating the molecular mechanism of lifespan extension effect revealed that Ot B could activate the FOXO transcription factor DAF-16.?Ot B could not further extend the lifespan of long-lived mutant of insulin/IGF-1-like receptor (daf-2).?In addition, Ot B also requires SIR-2.1 and CLK-1 which is an enzyme in ubiquinone synthesis, for lifespan extension. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5 mg/mL (5.42 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.08 mM), Sonication is recommended.
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| Keywords | β-amyloid peptide | βAmyloid | β Amyloid | Qingyangshengenin B | Inhibitor | inhibit | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid | Amyloid-β | Abeta |
| Inhibitors Related | Benzenesulfonamide | Deferoxamine Mesylate | Cromolyn sodium | HEPPS | Phytic acid sodium salt | Rutin | Resveratrol | 10-Undecenoic acid | 2,4-Di-tert-butylphenol | Chlorzoxazone | Methyl tridecanoate | Glimepiride |
| Related Compound Libraries | Anti-Aging Natural Product Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Alzheimer's Disease Compound Library | Natural Product Library | Saccharide and Glycoside Natural Product Library | NO PAINS Compound Library | Natural Product Library for HTS | Covalent Natural Product Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Bioactive Lipid Compound Library |
United States
