| Name | QPX7728-OH disodium |
| Description | QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases with antibacterial activity, used in research on bacterial infections. |
| In vitro | The efficacy of QPX7728 disodium against Pseudomonas aeruginosa was not affected by the OprD inactivation of carbapenem porins.
In strains with porin mutations, QPX7728 disodium (4 μg/ml) completely reversed KPC-mediated meropenem resistance. [1]
The combination of QPX7728 disodium and cefbutin had similar efficacy against all enzyme subgroups (MIC90 of 1-2 μg/mL). [2] |
| In vivo | In a neutropenic mouse model of thigh infection, QPX7728 disodium (12.5, 25, or 50 mg/kg intraperitoneally administered every 2 hours for 24h) was administered in combination with cephalosporins. The bacterial counts of two carbapenem-resistant Klebsiella pneumoniae strains were reduced by about 2 log CFU. [[3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 60 mg/mL (211.3 mM), Sonication is recommended.
DMSO : 80 mg/mL (281.73 mM), Sonication is recommended.
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| Keywords | QPX-7728-OH disodium | QPX7728OH disodium | QPX7728-OH | QPX7728 OH disodium |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Bacterial Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Infection Compound Library |
United States
