| Name | Quercetagetin |
| Description | Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM). |
| Cell Research | Cell Line: RWPE2 prostate cancer cells. Concentration: 0.1, 1, 10, and 100 μM. Incubation Time: 72 hours [2] |
| Animal Research | Animal Model: SKH-1 hairless mice model. Dosage: 4 or 20 nmol. Administration: Topical application; 28 weeks [3] |
| In vitro | Quercetagetin inhibits PIM2, PKA, and RSK2 (IC50s: 3.45, 21.2, and 2.82 μM). Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED50 is 3.8 μM [2]. |
| In vivo | Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively [3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (12.57 mM), Sonication is recommended. DMSO : 250 mg/mL (785.57 mM), Sonication is recommended.
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| Keywords | Quercetagetin | Pim1 | Pim kinases | Pim | Inhibitor | inhibit |
| Inhibitors Related | Hispidulin | TCS-PIM-1-4a | SGI-1776 | CK2/ERK8-IN-1 | M-110 | NSC756093 | Pim-1 kinase inhibitor 4 | AZD1208 | Pim-1/2 kinase inhibitor 1 | Pim-1 kinase inhibitor 8 | TP-3654 | K00135 |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Bitter Compound library | Anti-Aging Compound Library | Flavor Natural Product library | Immunology/Inflammation Compound Library |