| Name | Quercetin |
| Description | Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90. |
| In vitro | In xenografts of human prostate cancer LNCaP and PC-3 cells, the combined administration of Quercetin (75 mg/kg) and 2-methoxyestradiol effectively inhibits tumor growth. |
| In vivo | Quercetin inhibits TNF-induced LDH release, reduces EC-dependent adhesion of neutrophils to bovine pulmonary artery endothelial cells (BPAEC), and also suppresses DNA synthesis and cell proliferation in these cells. As a PI3K inhibitor (IC50=2.4 - 5.4 μM), quercetin strongly inhibits PI3K and Src kinases, moderately inhibits Akt1/2, and has a slight effect on PKC, p38, and ERK1/2. |
| Storage | Keep away from moisture | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.7 mg/mL (18.86 mM), Solution.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 4 mg/mL (13.23 mM), Sonication is recommended.
10% DMSO + 50% peg 300 + 5% Tween +35% Saline : 10 mg/mL (33.09 mM), Solution.
DMSO : 230 mg/mL (760.98 mM), Sonication is recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Quercetin | PI3Kδ | PI3Kγ | PI3K | Phosphoinositide 3-kinase | Mitophagy | Mitochondrial Autophagy | Inhibitor | inhibit | Autophagy | Apoptosis |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Hemin | Guanidine hydrochloride | Hydroxychloroquine | Ethyl linoleate | Formamide | Paeonol | Alginic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Natural Product Library | Anti-Viral Compound Library | Cosmetic Ingredient Compound Library | Immunology/Inflammation Compound Library | Flavor Natural Product library | Anti-Aging Compound Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
