| Name | (R)-Lisofylline |
| Description | (R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM) that interrupts IL-12 signaling-mediated STAT4 activation, making it useful for studies on the treatment of type 1 diabetes and autoimmune disorders. |
| In vitro | (R)-Lisofylline inhibits IL-12-induced T cell proliferation and Th1 differentiation without affecting IL-12 secretion[1]. |
| In vivo | In NOD mice, (R)-Lisofylline prevents β cell dysfunction by inhibition of STAT4 phosphorylation and ameliorates experimental allergic encephalomyelitis. (R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells, suppresses IFN-γ production, the onset of diabetes, and macrophage infiltration into islets. (R)-Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test. In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs. (R)-Lisofylline improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (160.53 mM), Sonication is recommended.
|
| Keywords | STAT4 | STAT | Pentoxifylline | metabolite | lysophosphatidic | LPS | Lisophylline | Lisofylline | Inhibitor | inhibit | immunomodulator | IL-12 | IFN-γ | diabetes | anti-inflammatory | acyltransferase | acid | (R)-Lisofylline | (R)Lisofylline | (R) Lisofylline |
| Inhibitors Related | Flubendazole | HODHBt | Nifuroxazide | Balsalazide disodium dihydrate | Astaxanthin | Cryptotanshinone | Niclosamide | Diosgenin | 2,4,5-Trimethoxybenzoic acid | Niclosamide olamine | Artesunate | Raspberry ketone glucoside |
| Related Compound Libraries | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Anti-Diabetic Compound Library | JAK-STAT Compound Library | Drug Repurposing Compound Library | Stem Cell Differentiation Compound Library | Anti-Prostate Cancer Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
United States
