| Name | (R)-(-)-α-Methylhistamine dihydrobromide |
| Description | (R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective, and brain-penetrant agonist of the H3 histamine receptor with high receptor affinity, capable of enhancing memory retention and attenuating cognitive impairment in rat models, making it a valuable pharmacological probe for elucidating central histaminergic signaling and H3 receptor-mediated modulation of learning and memory processes. |
| In vitro | (R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist with over 10 times the potency of histamine (HA). It exhibits weak affinities for H1 and H2 receptors, with pKi values of 4.8 and <3.5, respectively. The compound shows more than 1,000 times selectivity for H3-receptors compared to HA and over 200-fold selectivity over H4 receptors[1]. |
| In vivo | In mouse and rat models, intraperitoneal (i.p.) administration of (R)-(-)-α-Methylhistamine dihydrobromide (e.g., 6.3 mg/kg) decreases the steady-state levels of tele-methylhistamine (t-MH), a primary histamine metabolite, without changing total histamine levels. This indicates an inhibition of histamine turnover. In a rat model of anesthesia-induced amnesia, pretreatment with 10 mg/kg (i.p.) reverses memory retention deficits caused by Propofol [2][3][4]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | α-Methylhistamine Dihydrobromide | α-Methylhistamine | HistamineReceptor | Histamine Receptor | H3 Receptor | a-Methylhistamine Dihydrobromide | a-Methylhistamine | alpha-Methylhistamine Dihydrobromide | alpha-Methylhistamine | (R)()αMethylhistamine dihydrobromide | (R) ( ) α Methylhistamine dihydrobromide |
| Inhibitors Related | Undecane | Betahistine mesylate | Histamine dihydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Sodium butanoate | Nizatidine | Alginic acid | Mianserin hydrochloride | Trazodone hydrochloride | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
