| Name | Raddeanin A |
| Description | Raddeanin A is a natural triterpenoid saponin from Cyperus japonicus that inhibits histone deacetylase and is also a potent immunogenic cell death inducer with strong anti-angiogenic and anti-tumor activities. |
| In vitro | METHODS: Raddeanin A (NSC-382873) (1, 2, 5 μM, 20 hours) treated B16-HMGB1-Gluc and MC38-HMGB1-Gluc cells, and measured HMGB1-Gluc luciferase activity and extracellular ATP levels.
RESULTS Raddeanin A induced a significant increase in HMGB1-Gluc activity and ATP release in both B16 and MC38 cells in a dose-dependent manner.[2] |
| In vivo | METHODS: Raddeanin A (NSC-382873) (1, 2, and 4 mg/kg, intraperitoneally or intratumorally) was used to treat mice bearing a subcutaneous xenograft model of MC38 melanoma cells to investigate the effects of Raddeanin A on the immune control of tumor growth in vivo.
RESULTS Raddeanin A caused considerable suppression of tumor size and weight in MC38 tumor-bearing mice; Raddeanin A effectively suppressed tumor growth in mice bearing B16 melanoma; however, intratumoral treatment with Raddeanin A did not significantly alter mouse body weight. [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.00 mg/mL (2.23 mM), Sonication is recommended. DMSO : 82.50 mg/mL (91.96 mM), Sonication is recommended.
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| Keywords | Raddeanin A | prostate | osteosarcoma | NSC-382873 | NSC 382873 | Inhibitor | inhibit | HDAC | Cholangiocarcinoma | cancer | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Manganese chloride (tetrahydrate) | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
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