Product Number: R013039
English Name: Regadenoson Impurity 39
English Alias: ethyl 3,3-diethoxy-2-formylpropanoate
CAS Number: None
Molecular Formula: C₁₀H₁₈O₅
Molecular Weight: 218.25
As an ester impurity of regadenoson, the research advantages of this compound lie in:
Analyzing the by-product formation mechanism of acetalization or esterification reactions during regadenoson synthesis to optimize processes for controlling acetal ester impurity generation;
Serving as a reference standard containing aldehyde and ester groups to provide a standard substance for detecting easily oxidizable impurities in drugs, improving detection accuracy;
Helping study the impact of aldehyde and ester group structures on drug stability and toxicological properties to provide a scientific basis for formulating impurity control strategies.
Drug Development: Used as an impurity reference standard to identify and quantify Impurity 39 in regadenoson preparations, evaluating the purity of APIs and formulations;
Quality Control: Acting as a standard substance to validate the sensitivity of detection methods (e.g., HPLC or GC-MS), ensuring acetal ester impurity content meets pharmacopoeia requirements during production;
Stability Studies: Simulating aldehyde oxidation or ester hydrolysis pathways under drug storage conditions to assist in establishing storage conditions and shelf life.
Regadenoson is an adenosine A2A receptor agonist used for myocardial perfusion imaging. Its synthesis may involve acetalization of aldehyde compounds or transesterification reactions, resulting in the impurity ethyl 3,3-diethoxy-2-formylpropanoate. Since aldehyde impurities have strong reactivity and may affect drug stability or cause safety issues, research on this impurity is an important part of regadenoson quality control.
Current research focuses on:
Synthesis Process: Developing high-purity synthesis methods for acetal ester impurities to solve the purification challenge of easily oxidizable aldehyde compounds;
Detection Technologies: Establishing highly sensitive detection methods for this impurity using reverse-phase HPLC combined with UV detectors or gas chromatography;
Toxicological Evaluation: Studying the potential biological effects of aldehyde group structures through in vitro cytotoxicity experiments;
Process Control: Analyzing the influence of parameters such as acetalization reaction temperature and catalyst type on impurity generation to optimize conditions for reducing its content.
China
