| Name | RGX-202 |
| Description | RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coactivator 1α (PGC-1α). |
| Animal Research | The following animal groups were used for the experiment: (1) mice that were not subjected to injections (n = 10)—this group was used only for physiological tests and were not killed after the experiment;?(2) saline-treated mice (n = 8)—the volume of injections was 200 μL;?and (3) β-GPA-treated mice (n = 8)—concentration of β-GPA was 1 mg/kg/day.?The volume of injections was 200 μL.Injections were performed 3 times a week for 3 weeks.?The mice's weight and the total amount of consumed food and water were measured daily.?Once a week, a string test was performed.?Measurements of the oxygen consumption rates of live animals and the open field test were performed after the course of injections.?After 3 weeks, the mice were killed;?brain dissection was performed to extract the cortex and the ventral midbrain (VMB) for quantitative real-time polymerase chain reaction (qRT-PCR) analysis[2]. |
| In vitro | 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance[1] |
| In vivo | 3-Guanidinopropionic Acid(β-GPA) downregulated the expression of the β-oxidation genes.?Administration of β-GPA in mice for 3 weeks improved the animals' physical strength and endurance health, ie, increased their physical strength and endurance and alleviated anxiety.?β-GPA might be considered an adaptogene affecting both the muscle and brain metabolism in mammals[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Slightly soluble
H2O : 50 mg/mL (381.3 mM), Sonication is recommended.
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| Keywords | RGX-202 | RGX202 | RGX 202 | PPARγ | oral | mice | Inhibitor | inhibit | Endogenous Metabolite | creatine import | cancer | b-GPA | beta-GPA | apoptosis | AMPK |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Glycolysis Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Inhibitor Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library |
United States
