| Name | Rhein |
| Description | Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities. |
| In vitro | In diabetic nephropathy-afflicted db/db mice, Rhein effectively ameliorates diabetic renal lesions and mitigates hyperlipidemia by reducing plasma cholesterol (Chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), ApoE, and renal tissue transforming growth factor-β1 (TGF-β1). |
| In vivo | In chondrocytes, Rhein (35 µM) effectively inhibits the synthesis of IL-1β in human osteoarthritis synovium and exerts effects in cartilage by reducing the amount of IL-1R and inhibiting the production of NO induced by IL-1β. Additionally, Rhein is capable of inducing apoptosis in acute promyelocytic leukemia cells (HL-60). |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5.45 mg/mL (19.18 mM), Sonication is recommended.
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| Keywords | Rhein | ReactiveOxygenSpecies | Reactive Oxygen Species | NSC-38629 | NSC38629 | Bacterial | Autophagy |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Hemin | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Sulfamethoxazole sodium | Ethyl linoleate | Formamide | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Polyphenolic Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library |