| Name | Ribociclib hydrochloride |
| Description | Ribociclib hydrochloride (LEE011 HCl) is a selective, orally active cyclin-dependent kinase CDK4/6 inhibitor (IC50=10/39 nM) that blocks cell cycle progression and inhibits tumor cell proliferation. |
| In vitro | Ribociclib hydrochloride (LEE011) significantly inhibited the anchorage-dependent growth of 12 out of 17 neuroblastoma cell lines. Following treatment with Ribociclib hydrochloride (100 nM and 250 nM), neuroblastoma cell lines known to be sensitive to CDK4/6 inhibition (BE2C and IMR5) exhibited significant accumulation of cells in the G0/G1 phase of the cell cycle [2]. |
| In vivo | In CB17 immunodeficient mice bearing BE2C, NB-1643, or EBC1 parazacco spilurus subsp. spilurus xenografts, the dosing regimen of Ribociclib hydrochloride (200 mg/kg, oral gavage, for 21 days) was well tolerated, with no body weight loss or other toxic reactions observed in any xenograft model mice. During the 21-day treatment period, tumor growth was significantly inhibited in mice bearing BE2C or NB-1643 xenografts, though tumor regrowth occurred after drug withdrawal. In contrast, the tumor growth inhibitory effect was not significant in the EBC1 xenograft model [2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 8 mg/mL (16.99 mM), Sonication is recommended.
DMSO : 5.8 mg/mL (12.31 mM), Sonication is recommended.
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| Keywords | Ribociclib Hydrochloride | LEE-011 Hydrochloride | CDK6 | CDK4 |
| Inhibitors Related | Ribociclib | (E)-β-Farnesene | Amantadine | 2-Chloropyrazine | Kojic acid | Abemaciclib | Sodium citrate monobasic | Palbociclib | Abemaciclib methanesulfonate | Sodium Oxamate | Seliciclib | Dinaciclib |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
