| Name | Rimiducid |
| Description | Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-linking the FKBP domains. It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. |
| In vitro | AP1903, a bivalent 'dimerizer' drug that binds FKBP and induces Fas cross-linking.?A single 2-hour treatment eliminated approximately 80% of T cells, and multiple exposures induced further apoptosis.?T cells were eliminated regardless of their proliferation state, suggesting that the AP1903/Fas system, which contains only human components, is a promising alternative to HSV-tk for treating GVHD[2]. |
| In vivo | Constitutive hGH secretion provides a convenient and accurate way to monitor the number of viable cells in vivo because hGH has a serum half-life of only ≈3 min in mice. Over 3 consecutive days, we implanted these cells i.m. into nude mice, and treated the animals i.v. with various doses of Rimiducid, and then determined serum hGH levels as a measure of the number of surviving cells. Rimiducid (AP1903; i.v.,0.01, 0.1, 1, 10, and 100 mg/kg) elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg/kg[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Powder: -20°C for 3 years
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 135 mg/mL (95.63 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 2.5 mg/mL (1.77 mM), Sonication is recommended.
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| Keywords | Rimiducid | Inhibitor | inhibit | FKBP | FK506-binding protein | FattyAcidSynthase | Fatty Acid Synthase | Fas receptor | Fas | Apoptosis | AP-1903 | AP1903 | AP 1903 |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
United States
