| Name | Ritanserin |
| Description | Ritanserin (R 55667) is a long-acting, highly potent, relatively selective, orally bioavailable 5-HT2 receptor antagonist with an IC50 of 0.9 nM. |
| In vitro | METHODS: AML cell lines Kasumi-1 and KG-1α were treated with Ritanserin (R 55667) (10, 20, 30, 40, 50, 60 μM), and cytotoxicity was determined by CCK-8.
RESULTSRitanserin (R 55667) significantly reduced the proliferation activity of AML cells in a dose-dependent and time-dependent manner. [1]
Ritanserin (R 55667) has low activity against multiple receptors, including histamine-H1 (IC50, 35 nM), dopamine-D2 (IC50, 70 nM), adrenergic-α1 (IC50, 97 nM), and adrenergic-α2 receptors (IC50, 150 nM).[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.19 mM), Sonication is recommended. DMSO : 50 mg/mL (104.7 mM), Sonication is recommended.
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| Keywords | α2 receptor | α1-adrenergic receptor | α1 receptor | Serotonin Receptor | Ritanserin | R-55667 | R55667 | Inhibitor | inhibit | HistamineReceptor | Histamine Receptor | H1 receptor | DopamineReceptor | Dopamine Receptor | Dopamine | D2 receptor | D2 | Beta Receptor | AdrenergicReceptor | Adrenergic Receptor | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT2 receptor | 5-HT2 | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Undecane | Alverine citrate | Meclizine dihydrochloride | Dapoxetine hydrochloride | Cefaclor monohydrate | Hexamethonium Bromide | Famotidine | 1,8-Cineole | Sodium butanoate | D-Mannitol | Alginic acid | Cinchonidine |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Angiogenesis related Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |