| Name | Ro24-7429 |
| Description | Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects. |
| In vitro | Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[1]. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[2]. |
| In vivo | Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 140 mg/mL (513.33 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (14.67 mM), Sonication is recommended.
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| Keywords | Tat | RUNX1 | Ro24-7429 | Ro247429 | Ro24 7429 | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV-1 | HIV Protease | HIV | Apoptosis | anti-inflammatory | anti-HIV | antifibrotic |
| Inhibitors Related | Stavudine | Aceglutamide | Emtricitabine | Tamoxifen | Urea | Cysteamine hydrochloride | Lamivudine | Metronidazole | Formamide | Dimethyl phthalate | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Bioactive Compound Library | Pediatric Drug Library | ReFRAME Related Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Orally Active Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
