| Name | Rosamultin |
| Description | Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity. |
| Kinase Assay | A substrate, His-Lys-Ala-ArgVal-Leu-(pNO2-Phe)-Glu-Ala-Nle-Ser-NH2, Inc. For the HIV1 protease assay, the stock solution of the prepared enzyme was diluted. The extracts or compounds(Rosamultin) tested were dissolved in dimethyl sulfoxide (10% in the reaction mixture). A reaction mixture (5 uL) composed of 1 L of 50 uM sodium acetate (pH 5.0), 1 uL of a substrate solution, 1uL of the plant extract or compound solution, and 2 uL of HIV1 protease solution, was stirred, centrifuged, and then incubated at 37℃ for 1 hour in a microtube. A control reaction was performed under the same conditions without plant extract or compounds. The reaction was stopped by heating at 90 ℃ for 1 minute. Thirty-five microliters of autoclaved water was added into the reaction mixture, and an aliquot of 5 uL was analyzed by high-performance liquid chromatography (HPLC). |
| In vitro | Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 150 mg/mL (230.47 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.54 mM), Sonication is recommended.
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| Keywords | triterpenoid | Rosamultin | Protease | oxidative stress injury | Inhibitor | inhibit | HIVProtease | HIV-1 | HIV Protease | antioxidant |
| Inhibitors Related | Stavudine | Aceglutamide | Emtricitabine | Urea | Tamoxifen | Cysteamine hydrochloride | Lamivudine | Metronidazole | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Anti-Viral Compound Library | Saccharide and Glycoside Natural Product Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library |
United States
