| Name | Rottlerin |
| Description | Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation. |
| In vitro | Rottlerin (20 μM) shows cell proliferation in HMVEC. Rottlerin (20 μM, 2/6/24 hours) dramatically reduces the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC [2]. |
| In vivo | Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 6.02 mg/mL (11.65 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.94 mM), Sonication is recommended.
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| Keywords | Rottlerin | Protein kinase C | PKCη | PKCζ | PKCε | PKCδ | PKCγ | PKCβ | PKCα | PKC | PKA | NSC-94525 | NSC94525 | NSC-56346 | NSC56346 | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | CKII | CaM kinase III | Autophagy | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Emtricitabine | Guanidine hydrochloride | Hydroxychloroquine | Lamivudine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Viral Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Anti-infective Natural Product Library | TGF-beta/Smad Compound Library |